Prognostic factors for radiotherapy in parotid carcinoma – own material
- Lalova, V. Parvanova, K. Popov, I. Gergov, D. Katsarov, B. Krastev
Retrospective analysis of prognostic factors in patients with carcinoma of the parotid gland, who performed radiotherapy in USHATO, Sofia. Retrospective analysis of 51 patients (33 men and 18 women) with carcinoma of the parotid gland. The average age of presentation is 57.4 years and the follow up period is average 7 years. Patients with T1–T2 tumors are 27, with T3 – 11 and T4 – 13, only in 15 (29,4%) are found lymph node involvement (N+). Compared to the histological type 23,6% of patients have mucoepidermoid carcinoma, 17,6% have adenocarcinoma, 15,6% have adenoid cystic carcinoma, 13,7% have acinic cell carcinoma, 11,7% have epidermoid carcinoma, 6,1% with undifferentiated carcinoma and 3,9% with malignant pleomorphic adenoma, mixed tumor and clear cell carcinoma. The degree of malignancy of the tumor in 27% is G2, and in 73% is G3. Superficial parotidectomy is performed in 55%, total parotidectomy in 31.3% and biopsy in 13.7%. Percutaneous radiation treatment with a dose of 50 ÷ 70Gy is performed in all patients. Mortality analysis is performed on age, sex and signs of the tumor. A total of 17 (37.2%) patients died, 36.4% are male and 27.8% female. According to T, T4 tumors are predominantly 47.3%, T3 – 31,6% and T2 – 21,1%. Mortality in patients with NO is 58%, in N + – 42%, in G3 – 74% vs. 26% in G2. In deceased patients the most histologic types are: mucoepiderodermoid – 26%, epidermoid, adenoid cystic cancer and adenocarcinoma – 16%, and other types – 5.3%. From the retrospective analysis in the study negative prognostic factors аre T3–4 tumors, G3 degree of malignancy and lack of gender, age and lymphatic metastasis. There is a tendency for adverse prognosis in patients with mucoepiderodermoid, adenoid cystic, adenocarcinoma and epidermoid carcinomas.
Key words: CARCINOMA OF THE PAROTID