Irradiation technique of blood products with Linear accelerator
- Petrov, E. Encheva, N. Zheleva, Y. Gluhcheva, M. Kolchevska, R. Dukova
Blood products irradiation with ionizing radiation is used to prevent transfusion-associated graft-versus-host disease (TA-GVHD) during blood transfusion. Many Radiotherapy Departments worldwide develop institutional techniques depending on the available radiotherapy equipment and conditions. The aim of this work is to report an irradiation technique of blood products developed at Radiotherapy Department, University Hospital “St. Marina” using linear accelerator, for the needs of the Transplant center of the same hospital. High energy X-rays from a multimodal linear accelerator are used. Blood products are placed in a box and covered with rice. A reproducable geometry of the linear accelerator Clinac iX, Varian, was selected. The dosimetry plan for the irradiation of blood products was calculated achieving a homogeneous distribution of the absorbed dose. The developed technique offers unified procedure of blood product irradiation. The choice of water-equivalent rice medium fulfills the condition of dose-build up effect. The treatment plan ensures that blood products receive minimum irradiation dose of 25 Gy. The reported technique is effective with regard to the dose required to prevent the risk of developing TA-GVHD, using the maximum capacity of the available equipment without a need for new investments and no obstruction of the clinical workflow with patients. This is the first reported technique in the country for irradiation of blood products with a linear accelerator.
KEY WORDS: BLOOD PRODUCTS. BLOOD TRANSFUSION. TA-GVHD. BLOOD PRODUCTS IRRADIATION. LINEAR ACCELERATOR