Multiple cerebral amyloidomas – case report
CNS amyloidomas are rare. Amyloid is an insoluble fibrillar protein not stored in normal tissue. Under pathologic circumstances, it is deposited in the extracellular and intracellular spaces to produce amyloidosis. Proteins or polypeptides form characteristic fine fibrils. The factors that determine nodular vs. diffuse amyloid accumulation remain uncertain. Amyloid nodules as localized space occupying lesions are called amyloidomas. Within the central nervous system, neuraxial or extra-axial masses arise. Of these, the most common locations of this disease process in the CNS are in the spinal cord, cerebral white matter, leptomeninges, and gasserian ganglion. These lesions are frequently described as slow-growing, tumor like masses. We present a case of multiple cerebral amyloidomas that represented a diagnostic challenge. We describe a 60-year-old man with multiple amyloidomas. MR imaging showed a heterogeneous, enhancing multiple small masses in the deep cerebral white matter, thalamus, putamen, globus pallidus, nucleus caudatus and much smaller lesion in the cerebellum.
Key words: MULTIPLE CEREBRAL AMYLOIDOMAS. BRAIN MRI. GD ENHENCEMENT