Pulmonary veno-occlusive disease – the role of multidetector computer tomography. Case report, pathologic correlation and revue in the literature
- Genova, B. Bogdanova, M. Denev
Pulmonary veno-occlusive disease (PVOD) is a rare cause of the primary pulmonary hypertension (PPH) and involves predominantly post-capillary venules. Histologically the disease is characterized with thrombotic occlusion of the postcapillary venules with interstitial edema and fibrosis. The definitive diagnosis is based on histology, however due to significant risk associated with pulmonary biopsy the imaging methods, notably multidetector computed tomography (MDCT) play an important role in identification of the appropriate patiens. We present a case of 55-years old patient admitted to the hospital with a progressive respiratory failure and referred for pulmonary CT angiography (CTA) in order to rule out a pulmonary thromboembolism. We discuss the CT findings in PVOD and their correlation with the histologic changes and the possible differential diagnosis, based on our experience and on the literature data.
Key words: PULMONARY VENO-OCCLUSIVE DISEASE. PRIMARY PULMONARY HYPERTENSION. MULTIDETECTOR COMPUTED TOMOGRAPH