Primary mammary angiosarcoma – clinical case with literature review
- Marinova, B. Yordanova, I. Mihaylova, J. Stoyanova, D. Jovanovska
We present a rare clinical case of primary mammary angiosarcoma in a 48 y.o. woman. The lack of treatment for 3 years, has led to localy advanced tumor formation in the right breast, affecting the skin with significant bleeding. Radical mastectomy with axillary lymph node desection was performed in emergency. Solitary liver metastasis was visualized on chest&abdomen CT. A detailed literature survey regarding primary mammary angiosarcoma was performed. It has been emphasized the need of strict pathohistological and immunohistochemical diagnostics and multimodal treatment aproach. The primary mammary angiosarcoma with high grade of differentiation (G3) is an invasive vessel neoplasma with high risk of local recurrences and distant metastases. The multimodal complex treatment includes radical mastectomy with or without axillary desection. The adjuvant radiotherapy of the breast wall and adjuvant chemotherapy, are improving the local tumor control, as well as the disease free survival and overall survival.
Key words: PRIMARY MAMMARY ANGIOSARCOMA. RADICAL MASTECTOMY. RADIOTHERAPY. CHEMOTHERAPY. MULTIMODAL COMPLEX TREATMENT