Teratoma with malignant transformation in Neuroendocrine Carcinoma – a rare clinical case with pathohistological and immunohistochemical analyses
- Marinova, B. Yordanova, I. Mihaylova, T. Betova, B. Nachev, A. Alkusheva
We present a clinical case of 45 y.o. woman complaining of pain and heaviness in the region of the pelvis. A presacral multilocular cyst with size of 112 mm/97 mm was visualized on CT and MRI examinations. Following surgical removal of the cyst, the pathohistological examination confirmed mature teratoma with malignant transformation. The positive immunohistochemical expression to Synaptophysin, Chromogranin and Cytokeratin in the tumor cells cytoplasma confirmed the presence of high differentiated neuroendocrine carcinoma. After one year follow up, the disease progressed with distant metastases – one solitary hepatal metastasis and multiple bone metastases. In the literature survey we found a single cases of testicular, retroperitoneal and ovarial teratomas with malignant transformation in squamous cell carcinoma, sebaceum carcinoma, malignant melanoma, adenocarcinoma, sarcoma and neuroepidermal tumor. A similar case of teratoma with malignant transformation was not found described in the accessible medical literature sources.
Key words: MATURE TERATOMA. MALIGNANT TRANSFORMATION. IMMUNOHISTOCHEMISTRY. NEUROENDOCTINE CARCINOMA