Рентгенология & Радиология, 2010, XLІХ 288-293

Application of 18F- FDG PET for the diagnosis and
differential diagnosis of Alzheimer’s disease
and Lewy body dementia
  1. Klisarova1, N. Deleva2, I. Dimitrov2, P. Bochev1, B. Ivanov
    1Nuclear Medicine Department, and 2First Clinic of Neurology, “Sveta Marina” UniversityHospital

Alzheimer’s disease and Lewy body dementia are the two most frequent disorders among degenerative  dementias. Their clinical identification and differential diagnosis are often difficult in the early stages when, on the other hand, treatment is most effective. FDG-PET assessment of regional brain metabolism is a proven method and its application in demented patients ensures a higher diagnostic accuracy even at the preclinical stage. It helps resolving cases with difficult differential diagnosis as well. In this paper we discuss the application of the method in Alzheimer’s disease and Lewy body dementia; we present typical cases of both disorders, which were assessed by FDG-PET for the first time in Bulgaria, highlighting the methodology and the characteristic imaging findings.

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