Рентгенология & Радиология, 2013, LII 290-294

Radiation-induced hondrosarcoma – a clinical case from our practice

L. Marinova, I. Mihaylova, R. Georgiev
Abstract.

We present a clinical case of radiation – induced occipital extracerebral chondrosarcoma in 36 years old young man. The patient had undergone two brain operations 8 years ago due to oligodendroglioma in the left temporo – parietal area. These surgical interventions were partial and subtotal tumor extirpation, followed by local radiotherapy to the brain to a total dose of 56Gy. The necessity of immunohistochemistry (IHH) analysis for pathologic differential diagnosis in high grade brain and peripheral tumors was discussed. In this particular case a precise differential diagnosis between peripheral chondrosarcoma and Ewing sarcoma/pPNET is needed. Important risk factors for the development of radiation – induced brain tumors and chondrosarcoma, extremely rarely diagnosed, was discussed. A very accurate précising of the treatment radiation dose is needed in young patients with malignant brain tumors, not only in the surrounding healthy brain tissues, but also in other tissues, such as skin, subcutaneous layer and bone. The exceeding of the radiation dose in the bone above 45-50 Gy, increases the risk of radiation – induced sarcoma with latent period over 8 years.

Key words: HONDROSARCOMA. RADIOTHERAPY.RADIATION- INDUCED SARCOMA. COMPLEХ TREATMENT. IMMUNOCHISTOCHEMISTRY