Simultaneous development of craniopharyngioma and choroid plexus carcinoma in the childhood – а clinical case
- Marinova, I. Mihaylova, R. Georgiev
We present a clinical case of 9 years old girl with concomitant brain tumors – choroid plexus carcinoma and craniopharyngioma diagnosed in 2009. After three operations, cranio-spinal irradiation with boost for the remaining tumor located in left ventricular trigonum to a total dose of 55 Gy and 7 courses chemotherapy, local tumor control was achieved for the choroid plexus carcinoma. Four years following the achievement of local tumor control of the choroid plexus carcinoma, an increase of the tumor formation located in the left side of the pituitary was reported. The diagnosis cystic craniopharyngeoma was found during the surgical operation. With this clinical case we would like to stress on the achieved local tumor control following the complex treatment of carcinoma of the choroid plexus, as well as on the slow growth of simultaneously diagnosed craniopharyngeoma. This case report raises the question of the genetic predisposition of the brain tumors in children, as well as possibility of malignant transformation of craniopharyngeoma following radiotherapy. The differential diagnosis of neuroectodermal brain tumors requires immunohistochemical analysis and if necessary genetic analysis.
|key words: COMPLEX TREATMENT. CHOROID PLEXUS CARCINOMA СRANIOPHARYNGIOMA. RADIOTHERAPY.MALIGNANT TRANSFORMATION. SIMULTANЕITY|